induction of type 1 diabetes in diabetes-resista nt (bb-dr) rats
نویسندگان
چکیده
the biobreeding- diabetes prone (bb-dp) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the rt1 u major histocompatibility complex (mhc) haplotype and homozygosity for an allele at the lymphopenia (lyp) locus. lyp mutation is responsible for a peripheral t -lymphopenia. there are other genetic loci contributing to diabetes susceptibility in this strain. bb rats carrying wildtype lyp alleles are not lymphopenic and are resistant to spontaneous diabetes (diabetes r esistant [dr]). our study shows that thymectomy and exposure to one sublethal dose of g-irradiation (tx-r) at 4 weeks of age result in the rapid development of insulitis followed by diabetes in 100% of dr rats. administration of cd45rccd4+ tcrcb+ t cells from unmanipulated syngeneic donors immediately after irradiation prevents the disease. splenic t cells from tx -r induced diabetic animals adoptively transfer type 1 diabetes to t-deficient recipients. wag, wf and lew strains are resistant to tx -r induced insulitis/ diabetes. this novel model of tx -r induced diabetes in bb-dr rats can be used to identify environmental and cellular factors that are responsible for the initiation of antipancreatic autoimmunity.
منابع مشابه
INDUCTION OF TYPE 1 DIABETES IN DIABETES-RESISTA NT (BB-DR) RATS
The BioBreeding- Diabetes Prone (BB-DP) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the RT1 u Major Histocompatibility Complex (MHC) haplotype and homozygosity for an allele at the Lymphopenia (Lyp) locus. Lyp mutation is responsible for a peripheral T -lymphopenia. There are other genetic loci contributing to diabetes susceptibility in this strain. BB ra...
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چکیده ندارد.
15 صفحه اولmorphological evaluation of testis tissue of rats in various time points after diabetes type 1 induction
abstract objective: previous studies have indicated the hyperglycemia-induce cell death in various tissues such as brain, kidneys, liver and especially in the testis. recent studies have reported that diabetes can trigger male infertility. in this study we report the histological analysis of the testis tissue after diabetes type 1 induction in wistar rats. materials and methods: at various time...
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عنوان ژورنال:
medical journal of islamic republic of iranجلد ۱۸، شماره ۴، صفحات ۳۶۵-۳۷۰
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